四川大學生命科學學院導師：王亞軍 正文

　　
　　姓名：王亞軍　性別：男
　　職稱：教授　學院：生命科學學院
　　聯(lián)系方式：
　　辦公室電話：028-85415025
　　電子郵件：cdwyjhk@gmail.com
　　
　　學習與工作簡歷：
　　1987-1991: 西南師范大學生物系，理學學士。
　　1991-1994: 四川大學生物系，理學碩士。
　　1994-1999: 四川大學生物系 助教、講師。
　　1999-2003: 香港中文大學(The Chinese University of Hong Kong) 博士。
　　2003-2004: 香港中文大學（The Chinese University of Hong Kong）博士后。
　　2004-2007: 香港大學 (The University of Hong Kong), 博士后。
　　2007-現(xiàn)在： 四川大學生命科學學院 。

　　個人研究簡介：
　　斑馬魚作為模式生物一直在發(fā)育生物學、比較內分泌學等領域扮演重要角色。王亞軍博士在香港中文大學博士攻讀期間（1999-2003），以斑馬魚為研究模型，探究卵巢產(chǎn)生的一些生長因子，包括激活素（Activins）及其結合蛋白(Follistatin)，表皮生長因子（EGF）及其受體（EGFR），以及PACAP及其受體在控制卵泡發(fā)育與類固醇激素生成中的作用。 二零零四年，王亞軍博士加入香港大學理學院長梁志清教授實驗室從事博士后研究。以家雞為研究模型，圍繞神經(jīng)內分泌生長軸（調節(jié)生長發(fā)育的主要途徑）,致力于基因功能鑒定以及基因網(wǎng)絡調控解析，并首次在家雞等非哺乳類脊椎動物中鑒定到生長激素釋放激素 (GHRH)及其兩個專一性受體(GHRHR1 , GHRHR2)基因。 王亞軍博士的系列研究結果已先后發(fā)表在<Endocrinology>, <Biology of Reproduction>, <PNAS>等領域內著名刊物上。 回到四川大學后，王亞軍博士在四川大學引進人才基金支持下，組建畜禽功能基因研究平臺，主以家雞、斑馬魚為模型探究： 1) 神經(jīng)多肽 (如:GHRH, PrRP, GCG2等)、神經(jīng)遞質、生長因子等對垂體功能的調節(jié)及其胞內信號傳導機制；2) 基因功能及其表達調控; 3) 經(jīng)濟動物重要性狀形成分子基礎；4) 動物生長與代謝調節(jié)機制。
　　
　　研究方向：
　　動物細胞生物學、繁殖生物學、比較內分泌學
　　
　　項目支持：
　　國家自然科學基金、轉基因生物新品種培育重大專項、國家高技術研究發(fā)展計劃.

　　代表性論文：
　　1. Wang Y*, Wang CY, Wu Y, et al. Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology, 153: p1-14, 2012 (online) (*通訊作者) (IF=4.993).
　　
　　2. Wang Y*, Huang G, Li J., et al., Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280, 2012 (*通迅作者) (IF=4.118).
　　
　　3. Huang G, Li J, Fu H, Yan Z, Bu G, He X, Wang Y* Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology (online), p1-15, 2012 (* 通迅作者) (IF= 1.896)
　　
　　4. Ho JC, Kwok AH, Zhao D, Wang Y*, et al. Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L). General and Comparative Endocrinology 170: 391-400, 2011 (*通訊作者) (IF=3.108).
　　
　　5. Ruiqiang Li, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……, Yajun Wang*… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang. The sequence and de novo assembly of the giant panda genome. Nature, 463: 311-317, 2010 (IF=36.101)
　　
　　6. Wang Y*, Li J, Kwok AHY, et al., A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative endocrinology 166: 200-210, 2010. (IF=3.108)
　　
　　7. Wang Y*, Li J, C. Wang CY, et al., Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31, 2010 (IF=1.896).
　　
　　8. Lynch VJ，Tanzer A, Wang Y*, et al., Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. U S A. 105: 14925-14933, 2008. (IF=9.598)
9. Wang J, Wang Y*, Li X, et al., Cloning, tissues distribution and functional characterization of chicken glucagon receptor. Poultry science 87: 2678-2688, 2008 (IF=1.603)
　　
　　10. Kwok AHY, Wang Y*, Wang CY, et al., Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4) General and Comparative Endocrinology, 157: 99-106, 2008 (IF=3.108)
11. Wang Y*, Li J, Wang CY, et al., Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148: 2405-2416, 2007. (IF=5.045)
　　
　　12. Wang Y*, Li J，Wang CY, et al., Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440, 2007 (IF=5.045).
　　
　　13. Wang Y, Wang Z, Li J, Wang Y*, et al., A database for chicken full-length cDNAs. Physiological Genomics 28:141-5, 2007 (IF=3.368).
　　
　　14. Kwok AHY, Wang Y*, Wang CY, et al., Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues. Poultry Science 86: 423-430, 2007 (IF=1.603).
15. Wang CY*, Wang Y*, Kwok AHY et al., Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction. Journal of Endocrinology 195: 525-536, 2007 (IF=2.636) (同等貢獻).
　　
　　16. Wang CY, Wang Y*, Li J et al. Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development. Poultry Science, 85: 569-576, 2006, (IF=1.603).
　　
　　17. Kwok HF, So WK, Wang Y* et al, Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development. Biology of Reproduction, 72: 1370-1381, 2005 (IF=3.670).
18. Wang Y* & Ge W Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biology of Reproduction, 71: 749-760, 2004 (IF=3.670).
　　
　　19. Wang Y* & Ge W. Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction, 71: 2056-2064, 2004 (IF=3.670).
20. Wang Y* & Ge W. Cloning of zebrafish ovarian P450c17 (CYP17,17α-hydroxylase/17,20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues. General and Comparative Endocrinology, 135: 241-249, 2004 (IF=3.108)
　　
　　21. Wang Y* & Ge W Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology, 144: 491-499, 2003 (IF=5.045).
　　
　　22. Wang Y*, Wong AOL & Ge W Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology, 144: 4799-4810, 2003 (IF=5.045).
　　
　　23. Wang Y* & Ge W Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes. Biology of Reproduction, 69: 1998-2006, 2003. (IF=3.670)
　　
　　24. Wang Y* & Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology, 134: 308-315 (IF=3.108)
　　
　　25. Wang Y* & Ge W. Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology, 127: 209-216, 2002 (IF=3.108).
　　
　　會議報告
　　1) 王亞軍 The 10th International Symposium on Avian Endocrinology 2012 (ISAE2012) (June 5-9, 2012, Japan).（大會報告, Invited speaker）Title: ‘Molecular characterization of the receptors for chicken GHRH, PrRP and their related peptides: An emerging evolutionary story’
獲獎:
　　2003年度 “香港中文大學研究生最佳研究成績獎”
　　
　　
　　 

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