南京農(nóng)業(yè)大學(xué)植物保護(hù)學(xué)院導(dǎo)師：王源超 正文

　　王源超 老師個(gè)人簡(jiǎn)歷：
　　王源超，男，漢族，1968年11月生，山東榮成市人。1991年7月畢業(yè)于萊陽農(nóng)學(xué)院農(nóng)學(xué)系獲得學(xué)士學(xué)位，1996年7月畢業(yè)于南京農(nóng)業(yè)大學(xué)植保系獲得博士學(xué)位，1996年10月至1999年3月在浙江大學(xué)生物技術(shù)研究所從事博士后研究，1999年4月起在南京農(nóng)業(yè)大學(xué)工作至今。期間，先后在韓國、美國、加拿大和荷蘭等實(shí)驗(yàn)室進(jìn)行合作研究。現(xiàn)為南京農(nóng)業(yè)大學(xué)教授，博士生導(dǎo)師，植病系主任，植物病理學(xué)國家重點(diǎn)學(xué)科負(fù)責(zé)人，國家大豆產(chǎn)業(yè)技術(shù)體系病蟲害研究室主任。中國菌物學(xué)會(huì)理事，《植物病理學(xué)報(bào)》、《南京農(nóng)業(yè)大學(xué)學(xué)報(bào)》、《植物保護(hù)》、《生物安全學(xué)報(bào)》和《大豆科學(xué)》編委。
　　長期從事卵菌病害成災(zāi)機(jī)理以及植物疫病控制的應(yīng)用基礎(chǔ)研究，對(duì)檢疫性植物病原菌的快速檢測(cè)技術(shù)、疫霉菌對(duì)寄主識(shí)別的分子機(jī)理、疫霉菌致病性的變異機(jī)制等進(jìn)行了系統(tǒng)的研究。先后主持國家公益性行業(yè)科研專項(xiàng)、國家863計(jì)劃項(xiàng)目、國家自然科學(xué)基金、國家973計(jì)劃子課題和948項(xiàng)目等30余項(xiàng)。主要學(xué)術(shù)貢獻(xiàn)：（1）澄清了大豆疫霉對(duì)寄主識(shí)別的分子機(jī)理，發(fā)現(xiàn)了大豆疫霉通過G蛋白信號(hào)系統(tǒng)調(diào)控對(duì)大豆根系分泌異黃酮的識(shí)別從而尋找寄主植物，該研究為篩選新的控制疫病藥劑特供了重要的理論基礎(chǔ)；（2）明確了大豆疫霉毒性變異機(jī)制，克隆兩個(gè)新的大豆疫霉無毒基因、解釋了中國大豆疫霉群體中主要無毒基因通過點(diǎn)突變、轉(zhuǎn)座子插入和差異轉(zhuǎn)錄等方式進(jìn)行著復(fù)雜的毒性變異、證明了疫霉菌的毒性蛋白可以相互協(xié)作控制植物對(duì)病原菌的先天免疫，從而促進(jìn)病菌的侵染，該研究被選為植物學(xué)研究的頂級(jí)刊物Plant Cell的封面文章，研究結(jié)論對(duì)改良植物對(duì)卵菌病害的抗性有重要價(jià)值；（3）解釋了植物對(duì)疫霉菌非寄主抗性的分子機(jī)理，鑒定了多種新的疫霉菌分泌類毒性蛋白，采用病毒誘導(dǎo)的基因沉默技術(shù)澄清了MPAK等多種細(xì)胞信號(hào)系統(tǒng)在非寄主植物對(duì)疫霉菌抗性中的作用；（4）發(fā)掘了一批可用于檢疫性有害植物病原菌分子監(jiān)測(cè)的分子靶標(biāo)，并在此基礎(chǔ)上開發(fā)了十余種病原菌快速檢測(cè)技術(shù)，形成多項(xiàng)國家和行業(yè)標(biāo)準(zhǔn)，并得到廣泛推廣應(yīng)用。
　　先后獲得教育部自然科學(xué)獎(jiǎng)和科技進(jìn)步獎(jiǎng)3項(xiàng)、在國內(nèi)外刊物上發(fā)表研究論文100余篇，其中的包括Plant Cell、MPMI、Science等SCI期刊上論文50余篇，其中第一作者或聯(lián)系作者27篇，總影響因子83，論文被SCI刊物引用260余次，獲得國家發(fā)明專利5項(xiàng)，參編教材或著作3本。南京農(nóng)業(yè)大學(xué)“133人才工程”學(xué)術(shù)帶頭人，南京農(nóng)業(yè)大學(xué)優(yōu)秀研究生導(dǎo)師和優(yōu)秀教師，江蘇省“青藍(lán)工程”學(xué)術(shù)骨干，江蘇省優(yōu)秀科技工作者，江蘇省高校優(yōu)秀科技創(chuàng)新團(tuán)隊(duì)帶頭人，教育部新世紀(jì)優(yōu)秀人才。
　　 
　　研究方向：
　　1. 大豆真菌病害的成災(zāi)規(guī)律與綜合控制技術(shù)；
　　2. 植物疫病菌的功能基因組學(xué)；
　　3. 疫霉菌的分子遺傳學(xué)、分子進(jìn)化以及遺傳多樣性；
　　4. 重要檢疫性植物病原真菌的快速分子檢測(cè)、監(jiān)測(cè)與病害診斷技術(shù)；
　　5. 外來入侵生物學(xué)。

　　研究課題：
　　1. 農(nóng)業(yè)公益性行業(yè)科研專項(xiàng)，重要農(nóng)作物疫病菌致病型的分布與病害控制（3-20）
　　2. 國家高技術(shù)研究發(fā)展863計(jì)劃, 重要檢疫性植物病原菌快速分子檢測(cè)技術(shù)及試劑盒的研制（2006AA10Z433）
　　3. 國家大豆產(chǎn)業(yè)技術(shù)體系崗位科學(xué)家，大豆真菌病害
　　4. 國家 973計(jì)劃子課題，外來大豆疫霉入侵的分子生態(tài)適應(yīng)機(jī)制 （2009CB119200）

　　研究成果：
　　 1. Ye W, Wang X, Tao K, Lu Y, Dai T, Dong S, Dou D, Gijzen M, Wang Y. Digital gene expression profiling of the Phytophthora sojae transcriptome. 2011， Mol Plant Microbe Interact. Aug 17. [Epub ahead of print]
　　 2. Dong S, Yu D, Cui L, Qutob D, Tedman-Jones J, Kale SD, Tyler BM, Wang Y, Gijzen M.Sequence Variants of the Phytophthora sojae RXLR Effector Avr3a/5 Are Differentially Recognized by Rps3a and Rps5 in Soybean. PLoS One. 2011;6(7):e20172.
　　 3. Cui L, Yin W, Dong S, Wang Y.Analysis of polymorphism and transcription of the effector gene Avr1b in Phytophthora sojae isolates from China virulent to Rps1b. Mol Plant Pathol. 2011 Jul 4. doi: 10.1111
　　 4. Wang Q, Han C, Ferreira AO, Yu X, Ye W, Tripathy S, Kale SD, Gu B, Sheng Y, Sui Y, Wang X, Zhang Z, Cheng B, Dong S, Shan W, Zheng X, Dou D, Tyler BM, Wang Y. Transcriptional Programming and Functional Interactions within the Phytophthora sojae RXLR Effector Repertoire. Plant Cell. 2011, 23(6):2064-86. (cover story)
　　 5. Guo M, Chen Y, Du Y, Dong Y, Guo W, Zhai S, Zhang H, Dong S, Zhang Z, Wang Y, Wang P, Zheng X. The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae. PLoS Pathog. 2011, 7(2):e1001302.
　　 6. Wang Y, Huang Q. Assays for effector-mediated suppression of programmed cell death in yeast. Methods Mol Biol. 2011;712:173-80.
　　 7. Shen D, Ye W, Dong S, Wang Y, Dou D.Characterization of intronic structures and alternative splicing in Phytophthora sojae by comparative analysis of expressed sequence tags and genomic sequences. Can J Microbiol. 2011: 57(2):84-90.
　　 8. Baxter L, Tripathy S, Ishaque N, Boot N, Cabral A, Kemen E, Thines M, Ah-Fong A, Anderson R, Badejoko W, Bittner-Eddy P, Boore JL, Chibucos MC, Coates M, Dehal P, Delehaunty K, Dong S, Downton P, Dumas B, Fabro G, Fronick C, Fuerstenberg SI, Fulton L, Gaulin E, Govers F, Hughes L, Humphray S, Jiang RH, Judelson H, Kamoun S, Kyung K, Meijer H, Minx P, Morris P, Nelson J, Phuntumart V, Qutob D, Rehmany A, Rougon-Cardoso A, Ryden P, Torto-Alalibo T, Studholme D, Wang Y, Win J, Wood J, Clifton SW, Rogers J, Van den Ackerveken G, Jones JD, McDowell JM, Beynon J, Tyler BM. Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science. 2010, 10;330:1549-51.
　　 9. Zhao W, Dong S, Ye W, Hua C, Meijer HJ, Dou X, Govers F, Wang Y.Genome-wide identification of Phytophthora sojae SNARE genes and functional characterization of the conserved SNARE PsYKT6. Fungal Genet Biol. 2011,48(3):241-51
　　 10. Liu T, Ye W, Ru Y, Yang X, Gu B, Tao K, Lu S, Dong S, Zheng X, Shan W, Wang Y, Dou D. Two host cytoplasmic effectors are required for pathogenesis of Phytophthora sojae by suppression of host defenses. Plant Physiol. 2011, 155(1):490-501.
　　 11. Guo M, Guo W, Chen Y, Dong S, Zhang X, Zhang H, Song W, Wang W, Wang Q, Lv R, Zhang Z, Wang Y, Zheng X.The basic leucine zipper transcription factor Moatf1 mediates oxidative stress responses and is necessary for full virulence of the rice blast fungus Magnaporthe oryzae. Mol Plant Microbe Interact. 2010, 23(8):1053-68
　　 12. Meng J, Wang YC, Rapid Detection of Phytophthora nicotianae in Infected Tobacco Tissues and Soil Samples Based on Its Ypt1 Gene，J Phytopathol，2010，158:1 –7.
　　 13. Yonglin Wang, Aining Li, Xiaoli Wang, Xin Zhang, Wei Zhao, Daolong Dou, Xiaobo Zheng, Yuanchao Wang* GPR11, a putative seven-transmembrane G protei1 n coupled receptor, controls zoospore development and virulence of Phytophthora sojae,Eukaryotic Cell, 2010, 9(2):242-250.
　　 13. Li AN., Wang, YL., Tao K, Huang Q., Dong SM, Zheng, XB., and Wang, YC*, PsSAK1, a stress-activated MAP kinase of Phytophthora sojae, is required for zoospore viability and infection of soybean, Molecular Plant-microbe Interaction, 2010 Aug;23(8):1022-31.
　　 14. Cui LK, Yin WX, Tang QH, Dong SM, Zheng XB, Wang YC*, Distribution, Pathotypes and Metalaxyl Sensitivity of Phytophthora sojae from Heilongjiang and Fujian Provinces in China, Plant disease, 2010, accepted
　　 15. Tang QH, Gao F, Li GY, Wang H, Zheng XB, Wang YC*, First Report of Root Rot Caused by Phytophthora sansomeana on Soybean in China, Plant disease, 2010, 94(3):378
　　 16. Yonglin Wang, Daolong Dou, Xiaoli Wang, Aining Li, Yuting Sheng, Chenlei Hua, Binyan Cheng, Xiaoren Chen, Xiaobo Zheng, Yuanchao Wang* The PsCZF1 gene encoding a C2H2 zinc finger protein is required for growth,development and pathogenesis in Phytophthora sojae, Microbial Pathogenesis 47 (2009) 78 –86
　　 17. Dong S, Qutob D, Tedman-Jones J, Kuflu K, Wang YC, Brett M.Tyler, Mark Gijzen. (2009) The Phytophthora sojae Avirulence Locus Avr3c Encodes a Multi-Copy RXLR Effector with Sequence Polymorphisms among Pathogen Strains. PLoS ONE 4(5): e5556.
　　 18. Qutob D, Tedman-Jones J, Dong S, Kuflu K, Pham H, Wang YC, et al. (2009) Copy Number Variation and Transcriptional Polymorphisms of Phytophthora sojae RXLR Effector Genes Avr1a and Avr3a. PLoS ONE 4(4): e5066.
　　 19. Zhang H, Fang Q, Zhang Z, Wang Y, Zheng X.The role of respiratory burst oxidase homologues in elicitor-induced stomatal closure and hypersensitive response in Nicotiana benthamiana, J Exp Bot. 2009;60(11):3109-22
　　 20. Chen X R, Cheng B P, Wang X L, Dong S M, Zheng XB, Wang YC. Green fluorescent protein (GFP) as a vital marker for studying the interaction of Phytophthora sojae and soybean.Chinese Sci Bull, 2009, 54: 2822―2829
　　 21. Chenlei Hua, Xiaobo Zheng and Yuanchao Wang*，2009，G protein α subunit may help zoospore to find the infection site and influence the expression of RGS protein，Communicative & Integrative Biology 2:2, 1-3
　　 22. Yunzhe Gan, Lisha Zhang, Zhengguang Zhang*, Suomeng Dong, Jun Li, Yuanchao Wang* and Xiaobo Zheng，2009，The LCB2 subunit of the sphingolip biosynthesis enzyme serine palmitoyltransferase can function as an attenuator of the hypersensitive response and Bax-induced cell death，New Phytologist 181: 127 –146
　　 23. SM Dong, ZG Zhang, XB Zheng, YC Wang*, 2008, Mammalian pro-apoptotic bax gene enhances tobacco resistance to pathogens, Plant Cell Reports.
　　 24. DL Dou, SD kale, XL Wang, YB Chen, QQ Wang, X Wang, J McDowell, YC Wang, B Tyler, 2008, Carboxy-terminal motifs common to many oomycete RXLR effectors are required for avirulence and suppression of BAX-mediated programmed cell death by Phytophthora sojae effector Avr1b, Plant Cell 20: 1118 –1133
　　 25. Hua, C., Wang, Y., Zheng, X., Dou, D., Zhang, Z., Govers, F. and Wang, Y. (2008) A Phytophthora sojae G protein α subunit is involved in chemotaxis to soybean isoflavones. Eukaryotic Cell, in press
　　 26. Xiao-Ren Chen1, Xin-Le Wang, Zheng-Guang Zhang, Yuan-Chao Wang*, Xiao-Bo Zheng, (2008)Differences in the induction of the oxidative burst in compatible and incompatible interactions of soybean and Phytophthora sojae, Physiology and Molecular Plant Pathology,(2008)73: 16 –24
　　 27. J. Meng and Y. C. Wang*, 2008, First report of Phytophthora tentaculata on Aucklandia lappa in China, Plant Disease, in press.
　　 28. J. Meng and Y. C. Wang*, 2008, Rapid Detection of Phytophthora nicotianae in Infected Tobacco Tissues and Soil Based on Ypt1 gene, J of Phytopathology, in press
　　 29. Y Wang, Z Ren, XB Zheng, YC Wang*, 2007, Detection of Phytophthora melonis in samples of soil, water and plant tissue with polymerase chain reaction, Can. J of Plant Pathologhy, 29,172-181.
　　 30. XR Chen, G Shen, YL Wang, XB Zheng, YC Wang*, Identification of Phytophthora sojaegenes upregulated during the early stage of soybean infection，F(xiàn)EMS Microbiol Lett 269 (2007) 280 –288
　　 31. QH Chen, YC Wang, XB Zheng*, Molecular mapping of two cultivar-specific avirulence genes in the rice blast fungus, Magnaporthe grisea, Molecular genetics and genomics, 2007.
　　 32. ZY Wang, YC Wang* XR Cheng, G Shen, XB zheng, Differential screening reveals genes differentially expressed in low- and high-virulence near-isogenic Phytophthora sojae lines, Fungal Genetics and Biology 2006,43:826-839
　　 33. YC Wang WL Zhang XB Zheng*, Rapid and sensitive detection of Phytophthora sojae in soil and infected soybeans using species specific PCR assays, Phytopathology, 2006,96:1315-1321 .
　　 34. ZY Wang, YC Wang* XB Zheng*, Genetic relationships among Chinese and American isolates of Phytophthora sojae assessed by RAPD markers, Chinese Science Bulletin 2006, 51:2095-2102.
　　 35. ZG Zhang, YC Wang* XB Zheng, Molecualr detection of Phytophthora capasici, Plant Pathology, 2006，55:770-775 .
　　 36. ZG Zhang, XB Zheng*, Wang YC, KO WH. Evaluation of the rearrangement of taxonomic position of Peronophythora litchii based on partial DNA sequences. BOTANICAL STUDIES.
　　 37. J Zeng, YC Wang* XB Zheng, A Phytophthora sojae gene of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induced in host infection and its anti-oxidative function in yeast, Chinese Science bulletni,2006,51:1316-1324 .
　　 38. QH Chen, YC Wang, XB Zheng*, Genetic analysis and molecular mapping of the avirulence gene PR1, a gene for host-species specificity in the blast fungus magnaporthe grisea, Genome, 2006, 49:1-9 .
　　 39. J Li, ZG Zhang, R Ji, YC Wang* XB Zheng*, Hydrogen Peroxide regulates elicitor PB90-induced cell death and defense in no-head Chinese cabbage, Physiology and Molecular Plant Pathology, 2006 67: 220 –230.
　　 40. QH Chen, YC Wang, XB Zheng*, Genetic Diversity of DNA Fingerprint Haplotypes and Pathotypes in Magnaporthe grisea populations in China, J of Phytopathology ,2006: 154, 361 –369.
　　 41. ZJ Yu, ZG Zhang, YC Wang*, XB Zheng*. Molecular Detection and Monitoring of Fusarium oxysporum f.sp. niveum and Mycosphaerella melonis in Infected Plant Tissues and Soil, FEMS microbiology letter，2005, 249: 39 –47.
　　 42. R Ji, ZG Zhang, YC Wang* XB Zheng, Phytophthora elicitor PB90 induce apoptosis in tobacco W38 suspension cell, Chinese Science bulletin, 2005,50(5):435-439.
　　 43. G Shen, YC Wang*,XB Zheng. Development of a PCR Assay for the Molecular Detection of Phytophthora boehmeriae in Infected Cotton, J. Phytopathology, 2005, 153: 291-296-6
　　 44. ZG Zhang, YC Wang* , XB Zheng* , The Role of SA in Hypersensitive Response and Systemic Acquired Resistance Induced by elicitor PB90 of Phytophthora boehmeriae，Physiology and Molecular Plant Pathology, 2004，65：31-38.
　　 45. YC Wang*, DW Hu, ZG Zhang, ZC Ma, XB Zheng, DB Li, Purification and immuno- cytolocalization of a novel P Phytophthora boehmeriae protein inducing hypersensitive reaction and systemic acquired resistance in tobacco and Chinese cabbage, Physiology and Molecular Plant Pathology, 2003(4): 223-232
　　
　　 國家科技發(fā)明專利：
　　75. 大豆疫霉的檢測(cè)方法及其檢測(cè)試劑盒，專利授權(quán)號(hào)：ZL03131531.3；
　　 76. 苜蓿黃萎病菌的分子檢測(cè)試劑盒，專利授權(quán)號(hào)：ZL03131986.6；
　　 77. 一種防治農(nóng)田環(huán)境惡性雜草水花生的生物除草劑，專利授權(quán)號(hào)：03146132.8；
　　 78. 一種新的誘導(dǎo)植物系統(tǒng)抗病性的激發(fā)子及其制備方法，專利受理號(hào)：03131531.3, 專利公開號(hào)：CN1470173

　　獲得榮譽(yù)：
　　 1. 1999年度農(nóng)業(yè)部科技進(jìn)步二等獎(jiǎng)，疫霉菌生殖生物學(xué)與抗藥性研究；
　　 2. 2005年度教育部自然科學(xué)二等獎(jiǎng)，疫霉菌多樣性及其產(chǎn)生機(jī)制;
　　 3. 2007年度教育部科技進(jìn)步一等獎(jiǎng)，重要農(nóng)作物病原檢測(cè)試劑盒的研制與應(yīng)用

　　社會(huì)兼職：
　　 1. 中國菌物學(xué)會(huì)理事；
　　 2. 江蘇省植物病理學(xué)會(huì)理事
　　 3. 中國植物病理學(xué)會(huì)會(huì)員；
　　 4. 美國植物病理學(xué)會(huì)會(huì)員；
　　 5. 國際卵菌分子遺傳委員會(huì)成員；
　　 6. 美國遺傳學(xué)會(huì)會(huì)員；
　　 7. 《南京農(nóng)業(yè)大學(xué)學(xué)報(bào)》編委；
　　 8. 《大豆科學(xué)》編委；
　　 9. 《植物保護(hù)》編委

　　聯(lián)系方式：
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